5 Stars By R. Holzle on 2017-01-22
23andme vs Ancestry.com plus Promethease - [updated Nov 2017]
[see Nov 2017 Update under Promethease Results]
I had DNA analysis from 23andme. My wife had DNA analysis from both Ancestry and 23andme. This review is my comparison of the two. I highly recommend secondary analysis of your results by Promethease, see further discussion at end of this review. Basically I like 23andme. If 23andme offers a lower cost ancestry only test, this is OK. For developing an ancestry tree, Ancestry.com is MUCH better IF you signup separately for Ancestry's subscription search service.
TAKING TEST and SIGNUP – Very similar test taking. 23’s signup was more secure. Anc’s was easier, but they automatically put my wife’s test on my previously existing Ancestry account.
Waiting on RESULTS – Both send emails confirming sample receipt and when results were available. After logon, 23 provided step by step progress reports on the analysis process. The analysis process itself took about 10 days, including a holiday weekend. Total wait time was 3-4 weeks. Anc took 5 or so days longer than 23.
WEB SITE SECURITY – 23 is better. 23 requires a typical logon and password to get to the site. Anc automatically remembers your logon and password and just opens up when you go to the site. However, actually downloading your DNA file from Anc requires a full sign-on and confirmation link via your e-mail..
Ethnic Origin Analysis – 23 is much better (more correct). Anc included excessive Scandinavian content. 23’s discussion and analysis tools are much better.
DNA RELATIVE IDENTIFICATION – Recognizing that allocation of relatives to 1st, 2nd and 3rd cousins is somewhat imprecise. For my wife, 23 identified 4 second cousins and about 32 third cousins. Anc identified 1 first cousin, 2 second cousins and 9 third cousins. 23 also has ‘cousins’ outside the USA (in my case in the UK) which are really valuable contacts for ancestry searching. The web site does not directly identify a cousin’s location but you can easily guess this from supplementary info optionally provided by the cousin on 23’s site.
DNA RELATIVE CONTACT and ANALYSIS – Anc provides the e-mail for a contact and shared ancestors for each DNA relative. You get more when you pay for their regular Ancestry services, see below. 23 provides an internal messaging application for communicating with contacts. The application works but is rudimentary and unsuitable for more than brief messages (especially with MS Edge); exchanging e-mail address’s after contact is more satisfying. 23 has a couple levels of ‘sharing’ (aka privacy). If you enable sharing you have reasonably useful (but somewhat clunky, but better than Anc) tools to compare the DNA analysis of relatives who also share. This helps to group relatives from particular ancestors. I had 3 relatives contact me on 23. My wife has had no contacts via either 23 or Anc.
Anc provides a powerful tree searching tool IF you subscribe to the regular Ancestry service. This is expensive, in the range of $200/year or more. Given the moderate ‘tools’ in their basic DNA service, I view their DNA analysis as an (effective) teaser for their subscription service. UPDATE: I did signup for the Ancestry services and they are great. Specifically, with a subscription their DNA site shows a contacts pedigree chart if that contact already has built an Anc family tree. This is MASSIVELY better than 23's unsorted list of surnames. When you search for a particular name it searches all of the connected family trees - this is exceptionally useful.
I have problems with some browsers not opening some Anc connected data (document images). Google Chrome seems the most reliable.
MEDICAL INFO – Anc provides no medical info. In late 2016 23 had two test options - $100 for just the ancestry service and $200 for ancestry plus medical. The medical info provide by 23 is interesting but for most people, currently not very useful. The medical items they are allowed to report on by the FDA are limited to 40 or so rare genetic conditions-not useful for most people. UPDATE-As of April 2017, 23 now reports on your risk of 4 medical conditions, including Alzheimers. Their discussion/explanation of your risks for these conditions is specifically approved by the FDA and is reasonably understandable, informative, and useful.
If you are so inclined, you can participate (answer a lot of online questions) in 23’s medical research. This is probably 20 ten minute questions sessions. I did this and feel like it was useful for medical research.
Analysis of you DNA results by Promethease, a third party service, provides excellent medical info.
CONNECTION to PROMETHEASE – Promethease (Prom) is a third party service that assess’s your detailed DNA results from either 23 or Anc and provides a detailed medical risk report. Go to the Prom site to get started. The connection from Prom to 23 is especially easy. For Anc you have to separately download from Anc and upload to Prom which is also not too difficult. Cost is $5 per report.
PROMETHEASE RESULTS –Prom generates 20,000 or so reports (hits) from the 700,000 or so genes that are tested by 23 and Anc. 23 and Anc test a different set of genes, although they mostly overlap. For my wife’s test from both 23 and Anc the corresponding Prom reports were about 85% the same for the 40 most significant hits (Prom magnitude 2.5 and above). There were 5 or 6 unique hits in the top 40 for each report. I judge that the unique hits were about equally important, between 23 and Anc - none were critical.
[Nov 2017 Update] In October 2017 I resubmitted by 2016 23 test to Prom. About 15% of the hits were changed. A couple unusual hits were deleted. A very significant change was that one gene comment changed from 'increased risk of Type 1 diabetes' to '18x risk of Type 1 diabetes'!!! I read up on this. It turns out that the genetic > diabetes risk/connection is currently a very hot and complex research topic. The relevant research report was published in 2017. My suggestion is to update your Prom report every year or two if diabetes or alzheimers are a concern.
USING PROMETHEASE – IMPORTANT – Use of general DNA analysis to identify general medical conditions is an emerging (not well developed) technology/business. My guess is that the info provided by Prom is perhaps 30% or so of what will be available in 10 years or so. I regard the info provide as indicative, definitely not complete and possibly incorrect (due to either testing error or interpretation error).
Having said that, it is interesting, likely useful and potentially lifesaving. The information will be disturbing (negative), but in most cases not surprising. I think most people will be able to absorb the info without getting too stressed out. If you are a hypochondriac, this could be a problem. If you want a chance of good news, you can write down the stuff your are concerned about ahead of time, and then see if they actually show up.
My comments for using the report are:
• Make sure you download a copy to your PC for future reference, don’t just look at it online.
• After you figure out how to use the report, move the '0' Magnitude slider up to a range of 2.5 or so. This will limit you to the top 40 or so hits. Then go down to the bottom of the report and hit the '2X' bar a few times to see all the hits.
• You can then hit the ‘Table’ button at the top and print a summary of the hits to help see the big picture. You can also open this table in Excel and modify/save it for a more useful table. If you do this, add a Frequency column if it's not already there.
• To me, after Magnitude, the most important factor is ‘Frequency’. This is what percentage of the target population has this condition. If its around 40% or higher, I think it’s already ‘dialed in’ to the normal medical process – it is something your doctor and the medical community will look for in any case. Most of the hits fall into this category. If it’s less than 10%, it’s likely not on your doctors radar screen and you will want to consider if it’s worth mentioning to your doctor.
• The second most useful item is the relative increased risk in the item discussion. Recognize that the absolute risk is not provided – this could be 1 in 100,000, so a 1.1 relative risk is almost meaningless. On the other hand I looked up AMD (Age Related Macular Degeneration-eye problems) on the internet; it affects 1 in 3 to 5 people by age 80, so 2x risk is really significant. Good to know this ahead of time.
• After you assess the top 40, which takes a while, you can expand the Magnitude to it’s full range. Then click on ‘Topics’ and click on sub topics of interest and see if any common concerns emerge. Do the same for ‘Medical Conditions’. This seems like a lot of work but only takes an hour or 2 once you get started. For me the common themes seem to be heart disease, Alzheimer’s and Rheumatoid arthritis – none of which are a surprise.
- When you find something that might be relevant you NEED to do supplemental research on the Internet. The Prom report is a brief and simple identification. Fuller understanding can significantly change (reduce?) your concern for the issue. Be aware that there are 'hypochondriac' web site for some of these issues. I like to start with Wiki, Mayo Clinic and WebMD. Search for the Prom gene name 'rs........'. Then find out what the common term(s) for the gene is e.g. MTFHR and search for that. Write stuff down, gene names can be confusing.
• Again, remember this is an emerging technology, so the results will change from year to year for a while. I guess that in 10 years it will be a routine consideration in a physical.
5 Stars By Coastal Girl on 2016-11-30
SOLVED AN 83+ YEAR OLD MYSTERY OF MY GRANDFATHER'S IDENTITY
The testing is fairly simple: You receive a test vial (log in and register it on their website) and provide saliva up to the control line. Make sure you don't eat or drink for 30 to 45 minutes before providing your saliva sample. It is best not to brush teeth beforehand since it will only wash away valuable DNA and you want to ensure your sample has enough to process. Yes I had a few failed kits in my life and that set us back months of getting results on those kits. Anyway it’s fairly simple to provide saliva samples. Simple enough I had my 5 1/2 year old done and she was the easiest one to process. Then you place the kit back into included return envelope and wait for about 6 to 8 weeks for it to process. All while keeping tabs of the process online as each step finishes.
I started using 23andme in 2012 before the FDA had gotten nasty and demanded they stop providing such detailed health analysis. Most of the kits I purchased (all but 2) included the ancestry with health but the ancestry portion was the sole purpose for us using 23andme services. I have tested both of my parents, my two children, two paternal aunts, my daughter's paternal grandmother as well as myself and two cousins whom I tested to confirm our relationship. If you test at least one parent, you can easily sort matches that are shared with that parent to determine which matches are maternal and paternal. Since both my parents have tested mine literally shows who matches me from each side and my children can sort their matches based on me being tested too.
My paternal grandfather died in 1995 and took with him the secret of his past. He had ran away as a young boy and changed his name so we knew him only by the name he had taken. My family always yearned to know more about my grandfather's past but he had endured some sort of trauma or something and for whatever reason chose to never speak of it again. So we grew up only knowing half my father's ancestry - that of his mother.
After my grandfather died, I set out on a mission to try to figure out more about his past and his identity. I sent off for birth and school records and hit one dead-end after another trying to prove he was who he said he was. I spent hours going over census data on Ancestry's website, writing to courthouses across the country. The evidence pointed to the conclusion he was not who he said he was and so I had nothing solid to go by. Until 17 years into chasing cold trails, I discovered ancestry type DNA testing. I figured it wouldn't hurt to order my dad a kit and see where that would take us. If I could just find one close enough match then maybe it would give us a good lead on figuring out my grandfather's real surname.
After waiting for what seemed like months (it was actually only about 6 weeks) my dad's DNA was online (on 23andme’s secure site) and accessible along with all his many matches - which were basically cousins at various degrees of distance. It was one cousin (a predicted second cousin) in particular that gave me access to their family tree and actually dove in with me searching for clues that would lead us to my grandfather.
Just 6 months into researching my father's DNA, I found my grandfather's family and figured out who he really was. I wanted to ensure that my information was correct and so I contacted the daughters to the man I believed to be my grandfather's brother and offered to test them both. Their test results confirmed they were indeed our 1st cousins. I have since been in contact with close and distant family via this newly discovered paternal side and even obtained a copy of my grandfather's family surname book. His absence was even recorded in the book! I solved an 83+ year mystery and gained a family I longed my entire life to know about. I cannot be more thankful that these tests are available and that it gives us such ability to solve things that seem impossible.
Granted this all sounds way easier than it was and in all honesty it took planning and sorting and meticulous record-keeping to rule out my father's maternal matches. I literally mapped my father's DNA and researched every match labeling in an Excel document, which chromosome location that relative fit and what surnames fit within those matches. It’s given me new found respect and interest in knowing about each and every ancestor that left their mark within our DNA. It’s time-consuming, rewarding and addicting. I can say that with all honesty as I now manage 15+ kits on various DNA web sites. I tested myself and both parents on 23andme as well as AncestryDNA and Dad was also tested on FTDNA but I met my most useful matches on 23andme. It was on 23andme that I found the best ability to pour over chromosomes researching every detail I could.
Oddly between 23andme and Ancestry their tests show a discrepancy in ethnicity estimates. One shows that my dad has a tiny trace of Native American (23andme) yet AncestryDNA does not show any trace whatsoever of Native American. My son has confirmed Native American and was only tested on 23andme and his percentage came back at nearly exact what is on his BIA blood quantum card. So I lean in feeling more comfortable with 23andme’s ethnicity estimates.
IMPORTANT TO NOTE: You can take your raw data (once your DNA is processed) and download it from any of these DNA testing sites and upload them for free to GEDmatch. That site allows you to cross compare other matches on there from all the DNA sites. As long as others have their data on their too you can look at those matches and even see where the match is on individual chromosomes, etc. It’s a great tool to utilize along with your DNA testing sites.
FINAL THOUGHT: If you are looking to solve a mystery, 23andme is great. If you are looking to just fill in a family tree and you have a paid Ancestry membership or you are willing to pay for it, I would also suggest AncestryDNA. AncestryDNA gives you immediate access to your matches’ trees and you can in turn build on your own tree with the information. But if you are NOT a paid member to Ancestry, their AncestryDNA features are limited. I personally think its poor business practice for Ancestry to force people who already fork over money for the DNA kits to further pay to utilize services that should be totally included within the purchase of the kit. With 23andme, there are no additional hidden usage fees.
Whichever one you choose, be prepared to discover a new you.
5 Stars By Eileen on 2016-09-18
The Reason Behind the Mixed Reviews
This DNA test from 23andMe gives you a huge amount of raw data. If you're looking for medical information (not just ancestry), you are getting your money's worth. However, due to FDA regulations, they aren't allowed to interpret it for you beyond some very basic (and frankly unhelpful) reports. This is true for all DNA testing companies when it comes to medical information. The good news is that you can upload your 23andMe data to other websites and receive detailed reports. Promethease.com gives you detailed reporting for just $5 - everything from vulnerabilities to diseases, to genes associated with personality traits. Another commenter mentioned the MTHFR mutations, which are associated with many chronic illnesses. Geneticgenie.org will run your 23andMe results specifically related to these genes, and the report is free. And if you can afford it, the best way to interpret your results is to make an appointment with a genetic counselor, who you can find through NSGC.org. So, you're paying for the data with this test, and it's just a few extra steps to understand the data.
5 Stars By A. Roos on 2017-06-25
I Found My Dad
I'm a sperm donor baby. I followed the instructions, spit in the vial, and found my genetic father. Life is weird but good. Thanks 23andme.
4 Stars By Amanda V on 2017-05-19
I am happy I purchased this kit. I included some of my results in the pictures.
- Received it within two days and avoided shipping costs (that their website charges)
- Easy to use and instructions are simple
- I liked the updates and the timeline
- The results are easy to read
- A plethora of information
- If you family participates they will conjoin your ancestry reports to give you a better more accurate outlook into where you came from.
- Unfortunately due to FDA regulations 23andme had to remove a lot of content regarding the health portion. I will discuss alternate options below.
- Not completely accurate. It says I had a 6% chance of being a redhead, well I am very much a redhead and so are 6 members of my family, so the gene must be pretty strong.
- None of the health portions contained anything I was concerned about. Nice to know what it did provide.
- I wish the Ancestry portion was more details. I am 97% European, but of that 34% is Broadly Northwestern European wish I knew what that was. And if you change the confidence level from 50% to 90% you get different results (refer to pictures)
Now if you are not satisfied with the data 23andme provide you have other options. Since this data is yours you can upload the raw data from 23andme onto other sites. I did this with numerous other sites. I am not a geneticists so I can not say how accurate these websites are or even how accurate 23andme is. I wish we could upload this data into Ancestry.com, but of course they want you to buy their kit.
- DNA.land still need to read my results. I know it provides ancestry
- Promethease- costs $5, but offers a lot of data on health. Still can't seem to figure it out though, so much information...
- GEDmatch this is for ancestry, but database is still limited.
- Geneticgenie- This is for health and requires you do a lot of researching to figure out results.
5 Stars By Jess on 2015-01-01
Coolest thing EVER!
Buying this test was the best money I have ever spent in my entire life. The knowledge they give you is incredible. I wish everyone had a chance to know and understand their DNA. I wish 23andme was given automatically to all newborns. I just ordered kits for 3 family members.
23andme is not just ancestry, you get so much more. Here's a few things I got out of it...
1) I learned about my ancestry and how I am 24% Lithuanian, which was spot on as my grandma was born there.
2) I have at least 1000 cousins (3rd, 4th and 5th cousins.)
3) I can see a map of where my relatives are located and can be contacted/contact them if they also opted in for communication.
4) I learned I do not carry the breast cancer genes (thank god!)
5) I learned I do carry a mutation that lowers cholesterol and helps guard against heart disease (looked that gene up after seeing it in the news.)
6) Anytime I see any study in the news about genetics and how they found this gene associated with this disease etc, I can log in to 23andme, pull up my data and see if I carry that mutation or not. So geeky, but soooo cool.
7) I learned I have the mthfr mutation and was able to read more about what this means so I can make better choices regarding which types of folate I consume.
8) I learned I have a double mutation that effects b12 processing which could explain why I have always been low in b12. I will now ensure I get more b12 and monitor my levels with my doctor for the rest of my life.
9) I gained a new outlook on people. I think it's so incredibly that we are all essentially "written in code." It's this code that defines our health, how we look and to an extent, even how we act.
4 Stars By Fun Times Mom on 1969-12-31
Excellent Information Available.... Ancestry &/or Health (if you buy the $199 kit.. otherwise it's ancestry only)
FYI..23 and Me's current ad for Gru with Despicable Me currently shows a sample report of something like what you will see.
I bought both ancestry and health kits for my son and I. So, I don't know where the health information "cuts off" for those that only buy the ancestry kit for $99. I'm not sure if you will see the neanderthals gave you straight hair, brown eyes, back hair or not information. Either way, if you think you might want to purchase more than one kit, wait a little while after you submit your first kit and they will send you an email to purchase a second kit for a little less (I think it was $20 less). The other option is to purchase them when they have a sale around Mother's Day, Father's Day or Christmas. I haven't noticed a decrease in 2DayDeliver's prices (except Prime Day ..; and maybe Black Friday etc).
My ancestry is mostly unknown other than being "Caucasian".. since I don't really know my Father much and my Grandmother died long before I was conceived (at 36 years old from cancer). So, both sides of my family were vague. I didn't really care to know "my long lost relatives". My step-family I've grown up with keeps me more than busy. I was still curious about my general roots in ancestry and my son's since his dad was adopted. Ironically, I was more "Caucasian" than I was ever told. I am from Oklahoma and always heard of an old Great-Great Indian Grandmother somewhere along the line. If she existed, she conceived with a Scandinavian somewhere between the 1700's and 1820's. (Maybe I am proof the Vikings were here before Columbus...Just kidding..different time frame). I don't think this was the grandmother I was told about. I think she would have been more recent in my history. The funny thing is that the Native American only adds up to less than 0.1% of my genetics. The other 99.9% is all European. Your journey can be deep or just end with this basic information regarding ancestry.
You can stop reading now..
The following is more for those that care to dig a little.
After a little research into my maternal haplogroup and searching out my K2a line.. by way of google, I discover I am a very long distance relative to the short Neanderthal "ice man" they found. They recreated his image digitally. At first, I think... he doesn't look like anyone that I know, but then the resemblance kicks in if I take a few years off his face. He looks like an aged version of my mother (she has darker skin). LOL. It sounds like he had medicinal herbs for reflux, diarrhea, and a few other immune boosters in his attached bag. It's a little surprising, but not much since my mother is lactose intolerant (I missed that gene;). We suffer from allergies, arthritis, reflux and have a weakness for viruses. Why did I have to get those Neanderthal genes? I have 293 Neanderthal variants and my son has 307 but this still only makes up about 4% of our DNA. It pretty much seems that anyone found around Neander Valley, Germany around that time will have some Neanderthal genes to some degree. It wasn't the "your related to King/Queen, President" story one might hope for, but I still found it entertaining. ;)
Since I'm not a male, and my father's DNA can't be tested (he passed away), I won't know my Paternal Haplogroup. I was able to reserch my son's line, but I didn't find any entertaining stories. The description for areas for his group that was passed on through his Dad are very wide. Since we don't know his Dad's actual heritage (due to adoption), it makes it difficult to guess which smaller group or area he would belong to. I think the results were Turkey, Lebanon, Italy and Iran back in that time frame. The results can be fairly wide at times.
The main reason I brought up these two above scenarios is to show the range of experiences into broad research into heritage. My son has .8% African that he must have gotten from his Dad's line. I was actually surprised that I didn't have any African genes. The main reason for my surprise was because I thought it was fairly common in the US and yet I didn't even have a trace. I get keloid scars that are usually associated with the African race (I was told that by my dermatologist). You never know what you will find. Some things you that you think you know are wrong, and sometimes you might not learn that much new information, based on the accuracy of your tales you grew up with.
You will see if you carry genes for a lot of carrier status diseases that can affect birth like cystic fibrosis, PKU, sickle cell anemia, limb-girdle muscular dystrophy etc. There are 42 of these types of diseases listed in the report. Currently, they also specifically list late onset Alzheimer's, Parkinson's, Alpha 1 Antitrypsin and hereditary thrombophillia. There are some other's listed that you probably already know the answer to like, lactose intolerance, asparagus odor detection, bitter taste, sweet taste, hair type and color, freckles or not, eye color, unibrow etc.
If you really want to dig into your heath risks..
If you want to know BRCA, MTHFR, cardiovascular risks or other odd things... you will have to go submit your raw data to another DNA website that can be found though google. There are a couple. Do your homework before you decide. From free to a few more dollars a lot more information can be found based on your SNPs. There is even a Wikipedia website dedicated to SNPs for BRCA etc. You can even enter each number that begins with rs and see your raw data results for each of the different genes you are concerned abound. You must know what you are doing and understand if that gene requires one or two copies to put you at risk or makes you a carrier and how the A or C or whatever after it affects your risk. My two cents, just use one of the other sites available and input your raw data into them. Digging on you own can take a long time. Prometheus or something like it is one of these sites. After you get your results be sure to realize it isn't a guarantee you'll get that disease.. it just lets you see what "hand" you have to play with. Like in a game of poker. You still could be dealt a new card (based on environmental factors). If you think it will motivate you to decrease your odds of that risk by working out, eating healthier or maintaining your exams by knowing your potential "bad stuff" go for it. If you aren't sure you want to know then you probably shouldn't dig this much.
My Health digging discovery..
I was able to discover that I have inherited what appears to be all the cardiovascular risks for silent MIs, arrhythmias, and cardiovascular disease that my Dad gave to me. He had so many silent MIs by the time he was 39 years old the doctors told him he needed a heart transplant. My chest pains/angina and high cholesterol have been there since I was 32 years old, young and thin. My Dad's cholesterol was just a few total points away from my first cholesterol taken at 32 yrs. My numbers have never changed hardly, even as my weight went up. It doesn't seem that diet, exercise or statins affect my numbers much based on my past experience. I finally have new medication has done wonders to get my cholesterol down. Granted, I guessed I might have inherited my Dad's cardiovascular risks before I even bought this kit based on my life experiences with my high cholesterol and chest pains. I also discovered that my colon and/or uterine cancer risk is higher than the ovarian cancer everyone assumed my grandmother died of at 36 years of age (it was so far spread they basically guessed ovarian cancer based on her young age). I always thought I needed to be watchful for my ovaries when ironically she might have died from a different cancer. My father ended up dying of aggressive prostate cancer. I thought I didn't need to ever worry about colon cancer. I would have never been "worried" about colon cancer. Now I know the risk factors, and will have my exams regularly. I don't mind knowing this "truth" and I don't worry about it. I feel like it just helps me focus on things I might have overlooked and blown off before I found this out. It still only increases my risk a little more than the standard population based on my genes. I also discovered I carry a 10% increased risk for Type 1 diabetes. I was lucky enough to not have this at birth, so this is an example of where the increase in risk doesn't mean I will have it. The highest statistical risk for any "bad" genes I have was 10%. So you can have a higher risk profile and not "get whatever.." or you can have a slightly increased risk profile 1-4%, and actually still get "whatever".. Are these types of information things you want to know? If not, don't dig, if you can "handle the truth," without excessively worrying then go for it. :)
Meeting/sharing with relatives and research:
You have the choice when you sign up and at any time you can change your mind on how much information to share with others or with researchers along the way.
I have NOT tried to dig into my family tree on 23 and me... my 2 closest relatives aren't sharing information anyway. They still appear to be distant (3-4th) cousins. Update: I now have a second cousin that is in the system and I sent a message to him. It turns out my Mom already knows him a little (and has met him and his family). He hasn't replied to me yet and it's been a while. The ironic thing is I can't seem to change or edit my message to him or send him an additional one. I hope 23 and Me fixes this somehow. Until then..Be careful with your initial messages. They might be the only one they ever see. Lol
The nice thing is about 23 and me that I have already seen is ... as updates to health profiles or genetic discoveries are made (or allowed to be shared by 23 and me, due to FDA regulations) they will update your profile. I get emails that ask if I want to know this information before they share it with me. You can always opt out if this is your choice.
A recent update was whether or not you want to know if you are a carrier for AMD. Ironically, my son is, but I am not. They also added Celiac disease to the list. My son and I are both carriers for one of the genes. I now try not to eat as much wheat etc. if there is a choice. My son and I have had issues with abdominal pain and from what I understand we could convert at anytime (or never), but I figured a little less wheat, rye and barley exposure may not be a bad thing in our case. I also recently discovered on my own (not through a 23 and me update by email) that my son and I both carry the JAK2 mutation (associated with polycythemia and possibly turning into blood cancers/ MPN's someday). I had Polycythemia (High Hemoglobin) for a while in my 20's that disappeared after a few years of being on a medicine that they use to treat it. I thought maybe the doctors made a mistake with my diagnosis since my blood has been pretty normal for quite a few years now. Anyway, while reading the 23 and me blog, I discovered that the majority (around 95%) of people with polycythemia have this JAK2 mutation. I searched my raw data for the SNP/rs# and there it was... I have the JAK2 mutation. So having the mutation doesn't mean you WILL get it, but it just increases the odds a little. Somehow, I have managed to keep it away without medication for years now inspite of having symptoms in the past.
Note: The 23 and me blog can be easily accessed and can give you an idea of some of the genetic discoveries/associations they have found. While it's not an all inclusive list that they test you for.. (yet) of all possible genes for all the health risks available, they are making some interesting discoveries that can maybe help "clear" up some risks or challenging cases.
If you have any more questions you are welcome to ask me.. I might know the answer and will gladly help you if I can.
1 Stars By Luke on 2017-08-19
Love/Hate relationship with 23andme
I've purchased three DNA Test Kits (one from 23andme, one from ancestry.com, purchased here on 2DayDeliver, see my review, and most recently the DNA test kit through National Geographic...)
I did my test with 23andme in 2014 and the results came after about 9 weeks. It was incredible and fascinating to see the information provided in this test and my parents and grandparents always to me I was an equal mixture of English, Scottish and Irish. (Our family names for generations pretty much also reflect the links to Great Britain.) 23andme confirmed what my grandparents on both side of our family had been telling me when I was very young.This was so interesting, that I bought another 23andMe test kit for my wife.
23andme nearly overwhelmed me with information not only in regard to where I came from, but with information about possible health issues I could probably have. I'm about to turn 66 as I write my review, and I'll say looking back at my medical ailments over the years, the health info was about 98% accurate, despite missing multiple sclerosis (which I was diagnosed with at age 60) and 23andme suggested I am prone to psoriasis (which I nor any member of my family has ever had.
My major disappointment with 23andme came earlier this year (2017) when they sent out info stating they were going to be selling my (and everyone else's data) to third party entities. Like Hell, I want my personal information to be sold to a corporation! I sent 23andme an email telling them to drop me as a customer, and that I did NOT want them releasing my personal information to anyone.
About 10 days later I received an email from them staying my account was closed and all I have now are some vague memories of the maps on 23andme showing migration patterns of my ancestors, some recollections of other info and questions as to why long-after I paid my $200, 23andme decided to "prostitute" me (and everyone else using their DNA test kit) AFTER I agreed to their original terms back in 2014.
I'd love to meet Anne Wojcicki (CEO and co-founder of 23andme) so I could say to her in my bad impression of Arnold Schwarzenegger voice, "Hasta la vista baby, I WON'T be back." And neither will my wife!
5 Stars By R. Eugene on 2016-11-08
the results are AWESOME and he loves it
I bought this for my husband.. the results are AWESOME and he loves it. However, I am apparently married to a Neanderthal.
5 Stars By 2DayDeliver Customer on 2017-01-22
Buy the $99 Kit
Excellent, but I would get the $99 kit over the $199 one. Then go to Promethease.com and dna.land.com and import your results (when their available from 23andMe), For $5.00 they give you loads of medical and other misc. insights from your genetic information. Importing is quick and easy, do it right from the Promethease website (links to 23andMe directly and grabs your data. dna.land requires you to upload data yourself). Just be sure to download a copy of the final results to your computer for future reference (as Promethease will automatically delete information from their servers after 4 months). DNA.LAND is free (it's a research project) well worth the extra effort and produces some more interesting results.